Asian Journal of Research in Chemistry

Sambhaji P. Vartale ¹, Vijay N. Bhosale ¹, Sharad V. Kuberkar ¹, Jagannath S. Jadhav ²

Affiliations
1 P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, IN
2 Department of Organic Chemistry, N.S.B. College, Nanded-431605, IN

Abstract

Pyrazolo pyrimido benzothiazoles (4a-i) were prepared by the reaction of compound 3-cyano-4-imino-2-methylthio-8-methyl-4H-pyrimido[2,1-b] benzothiazole (3) with hydrazine hydrate, substituted phenyl hydrazine, 2-hydrazino benzothiazole and 6-substituted 2-hydrazino benzothiazole in N,N-dimethyl formamide and catalytic amount of potassium carbonate. The synthesized compounds were characterized by elemental analysis, IR, PMR and Mass data.

Keywords

N,N-Dimethyl Formamide, Potassium Carbonate, Pyrimodo Benzothiazole, Pyrazole.

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Vijay N. Bhosale ¹, Sambhaji P. Vartale ¹, Sarla N. Kalyankar ¹, Jagannath S. Jadhav ², Sharad V. Kuberkar ¹

Affiliations
1 P. G. Department of Organic Chemistry, Yeshwant Mahavidyalaya, Nanded-431602, IN
2 Department of Organic Chemistry, N.S.B. College, Nanded-431605, IN

Abstract

8-Chloro-3-cyano-2-methylthio-4-oxo-4[H]-pyrimido-[2,1-b] [1,3] benzothiazole has been prepared by the reaction of 6-Chloro-2-amino benzothiazole with ethyl-2-cyano-3,3-bismethylthioacrylate in the presence of diemethyl formamide and anhydrous potassium carbonate. Suspectibility of compound towards condensation with different reagents like aryl amines, heteryl amines, phenols and compound containing active methylene group has been investigated.

Keywords

8-Chloro-3-Cyano-2-Methylthio-4-Oxo-4[H]-Pyrimido-[2,1-b] [1, 3] Benzothiazole, Ethyl-2-Cyano-3, 3-Bismethylthioacrylate.

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